Human EGFR Gene Mutation Detection Kit
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EGFR Gene Mutation Detection Kit is a PCR-based in vitro diagnostic test designed to detect 11 types of common mutations of human EGFR gene in DNA specimen of clinical tumor patients for targeted drug therapy.
Product Features:
- High Sensitivity: accurately detect 1% of mutantDNA from 10ng of the wild-type gene
- High Specificity: effectively improve the testing specificity by ARMS-PCR detection technology
- High Accuracy: closed tube reaction effectively prevent false negative and false positive results through the standard internal system and UNG enzyme system
- Quick & Easy: easy to operate with reliable results analysis, 90 mins to complete
Product Information
| Cat.No. | Product Name | Technology | Specification | Supply Format |
| YZYMT-002 | Human EGFR Gene Mutation Detection Kit | PCR-Fluorescence Method | 12 tests/ kit, 24 test/kit | RUO/CE-IVD |
Clinical Significance
EGFR (Epidermal Growth Factor Receptor), which is normally embedded in the cell membrane on the surface of cells, is a membrane protein that plays an important role in the proliferation, growth, repair and survival of tumor cells.The positive rate of EGFR gene sensitive mutations in patients with lung adenocarcinoma is 40%-50%. There are a variety of mutations in the tyrosine kinase domain of EGFR gene, which are mainly located in exons 18-21, among which exon 9 deletion mutation and exon 21 L858R mutation are the most common.
EGFR Gene Mutation Type Detected by the Kit
| Exon | Mutation Type | Mutation Rate | Clinical Guidance |
| 18 | G719A/G719S/G719C | 3-5% | Sensitivity |
| 19 | Glu746-Ala750del | 45% | Sensitivity |
| 20 | S768I | 3-5% | Sensitivity |
| T790M, Ins | Insensitive to EGFR TKIs Generation I &II,EGFR mutation and drug
resistance patients are sensitive to EGFR-TKI Generation III, oseltinib and ametinib. |
||
| 21 | L858R, L861Q | 45% | Sensitivity |
EGFR Gene Corresponding Targeted Drugs
| Molecular Typing | Corresponding Targeted Drugs | Available on Market or not |
| EGFR Mutation | Gefitinib, erlotinib, icotinib
Afatinib, daclatinib, osimertinib |
Yes |
| Almonertinib | Yes |