Circulating Tumor Cell Separator

Circulating Tumor Cell Separator CTCBIOPSY-A10 is a physics-based automated blood abnormal cell separation instrument, the unique polymer nano micro-screen filtration technology can efficiently, accurately and reliably capture abnormal cells in the blood, providing a convenient and efficient solution for tumor screening.

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Easy Operation:

  • High automation, 10 mins to complete CTC capture and enrichment of 5mL of whole blood.
  • Nano-microscreen technology, no reliance on sepecific cell marker, suitable for most solid tumor types.

Exclusive CTM:

  • No lysis of red blood cells or pre-centrifugation to preserve the CTM intact, direct observation.under microscope.
  • CTM can be accurately classified to screen out patients with the highest risk of metastasis with neutrophil CTM.

Sufficient Data:

  • The detection platform with international patents, the first CTC equipment in China to obtain NMPA registration certificate in 2015.
  • More than 100,000 clinical samples have been verified in over 200 hospitals.
  • Independently carry out downstream analysis such as IF, IHC, FISH and sequencing to meet the requirement of clinical research.

Technical Data

Specifications CTCBIOPSY-A10
Cat.No. YZY-A10
Function Sample separation
Throughput Single
Automation Fully automated separation
Processing Time 12 min
Dimension (W x D x H) 350 *300 *271mm

Circulating Tumor Cell (CTC) detection offers advantages such as non-invasive, real-time monitoring. It serves as a powerful tool for guiding personalized treatment in breast cancer patients. CTC testing can replace or complement tissue samples for pathological diagnosis, prognosis assessment, and subtype analysis. Additionally, dynamic CTC monitoring aids in disease progression evaluation and treatment efficacy assessment. CTC counts hold prognostic value for both early-stage and metastatic breast cancer. Notably, in early-stage breast cancer, a CTC count ≥1 signifies the presence of minimal residual disease (MRD) or indicates poorer prognosis.

CTCs can be thought of as a liquid biopsy from the blood. The clinical applications of CTCs include  selection and monitoring of therapeutic regimens; and drug target applications.

Utilizing suction filtration technique to separate CTC and CTM from the red blood cells in the whole blood. CTC and CTM are retained on the membrane.

The membrane is nano-microsieve with 13 mm in diameter. It has 160,000 micropores. The pore size is uniform (8 um), and the inter-pore distance is also uniform (25 um). It allows for efficient enrichment of CTCs, making CTCs visible under a regular microscope.

The micro sieve membrane is second-generation nano polymer material. It is resistance to various staining reagents with good light transmission. It allows us to directly observe the CTC under microscope.

High automation, 10 mins to complete CTC capture and enrichment of 5ml of the whole blood .
Nano-microscreen technology, no reliance on specific cell marker, suitable for all types of tumors.

Circulating Tumor Cell (CTC)

CTCs are found in the blood as either single cells, bound together in tight ‘microclusters’, and/or clustered together with immune cell

Circulating Tumor Microemboli (CTM)

Have at least 3 CTCs Play an important role in tumor metastasis. The metastasis risk increases by 23-50 times.

CTC Neutrophil Clusters (Neutrophil CTM)

CTC neutrophil clusters, representing a critical weakness in the metastatic process, the link between neutrophils and CTC drives the progress of cell cycle in the blood flow and expands the metastatic potential of CTC. The survival period decreases by 5 times.

Tumor Metastasis Risk: CTC < CTM < Neutrophil CTM

1. Cell diameter (longest side) > 15µm;
2. Nuclear-to-cytoplasmic ratio (NCR) > 0.8;
3. Abnormal nuclear morphology, such as lobulated or mulberry-like nuclei;
4. Hyperchromatic and unevenly stained nuclei;
5. Thickened nuclear membrane with indentations or folds, resulting in an irregular nuclear shape;
6. Presence of giant nucleoli;

※ A single CTC (Circulating Tumor Cell) is defined as meeting 4 or more criteria.
※ A cluster of 3 or more CTCs is referred to as a CTM (Circulating Tumor Microemboli).
※ When a CTM combines with a neutrophil, it is referred to as a Neutrophil CTM. Complying with 4 or more items is considered a single CTC.

CTC pathology detection is the gold standard – classic technology

IHC

IF

FISH

Cell Culture

High automation, 10 mins to complete CTC capture and enrichment of 5ml of whole blood .
Nano-microscreen technology, no reliance on specific cell marker, suitable for all types of tumors.
No lysis of red blood cells or pre-centrifugation to preserve the CTM intact, direct observation under microscope.
Autonomous downstream analyses, such as IF, IHC, FISH and sequencing to meet the requirements of clinical research.

Optimized isolation technology by size of epithelial tumor cells (ISET) can accurately and reliably capture abnormal cells in blood, providing a efficient solution for tumor screening.

Quick Separation

 

No reliance on cell marker for separation
Single sample isolation time <10 mins

Easy Operation

 

Friendly operation interface
Sorting of samples with one click
Real-time display of blood sample processing

Authoritative Identification

 

Norms for identification of cell morphology
formulated by authoritative pathology experts

Quick Separation

 

No reliance on cell marker for separation
Single sample isolation time <10 mins

ISET technology uses the size and deformability of tumor cells to achieve separation, then use cell morphology for identification.

CTC detection data of the CTC-BIOPSY® system in 2018-2020 showed an average CTC detection rate for each tumor is 80.90% ,CTM (Circulating Tumor Microemboli) detection rate is 12.52%, and the ratio of CTM to total CTC detection was consistent with study data from Nature in 2019.

Partial Detection Data of CTC and CTM from 2018 to 2020:

Responsive Table
Type Total cases Detected Qty Detection rate Mean Median
CTC 7527 7527 80.90% 7527 3
CTM 9304 1165 12.52% 1165 0
CTCs 7686 7686 82.61% 7686 3

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