Human CYP2C9 & VKORC1 Gene Detection Kit
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CYP2C9 & VKORC1 Gene Detection Kit is a PCR-based in vitro diagnostic test designed to detect polymorphism of CYP2C9 CYP2C9*3 and VKORC1 VKORC1-1639G>A in whole blood samples. This kit is used to provide a reference for clinicians’ individualized medication.
Corresponding Drugs: Warfarin, Ibuprofen
| Easy Operation
·Unique fluorescence PCR technology ·Each sample occupies only one reaction well ·90 mins to complete |
Simple Results Analysis
·Simplified analysis without △CT value reading ·Simple training |
Wide Sampling Types
·Blood/saliva/oral swab type |
Product Information
| Cat.No. | Product Name | Technology | Specification | Supply Format |
| YZYMT-007 | Human CYP2C9 & VKORC1 Gene Detection Kit | PCR-Fluorescence Method | 20 tests/ kit | CE-IVD/RUO |
Warfarin is a widely used oral anticoagulant in clinical practice. However, warfarin dosing is difficult to master. Bleeding side effects occur in 15.2% of patients taking warfarin each year. CYP2C9 and VKORC1 gene polymorphisms are closely related to anticoagulant efficacy, and patients with different genotypes require different doses of warfarin
Ibuprofen is a non-steroidal anti-inflammatory drug. CYP2C9*3 mutation can reduce the metabolic activity of ibuprofen, enhance the efficacy of ibuprofen, and cause potential adverse drug effects such as gastrointestinal bleeding in individuals carrying this mutant allele.
Genotype Detected by This Kit
| Gene | Gene Polymorphism | Base Change | Mutation Frequency | Medication Guidance |
| CYP2C9 | CYP2C9*3 | ATT>CTT | 2%-5% | Warfarin dose reduction
required for mutations |
| VKORC1 | Mutation type | G>A | 80%-90% |
