Human KRAS Gene Seven Mutation Detection Kit

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KRAS Gene Mutation Detection Kit is a PCR-based in vitro diagnostic test designed to detect 7 somatic mutations in codons 12,13 of KRAS gene in human genomic DNA extracted from formalin-fixed paraffin-embedded (FFPE) tumor samples of clinical tumor patients for targeted drug therapy.

Product Features:

High Sensitivity: accurately detect 1% of mutant DNA from 10ng of the wild-type gene
High Specificity: effectively improve the testing specificity by ARMS-PCR detection technology
High Accuracy: closed tube reaction effectively prevent false negative and false positive results through the standard internal system and UNG enzyme system
Quick & Easy: easy to operate with reliable results analysis, 90 mins to complete

Product Information

Cat.No.	Product Name	Technology	Specification	Supply Format
YZYMT-001	Human KRAS Gene Seven Mutation Detection Kit	PCR-Fluorescence Method	12tests/ kit, 24tests/ kit	CE-IVD/RUO

Clinical Significance

KRAS is a proto-oncogene and a member of the RAS gene family. The protein encoded by this gene is related to the formation, proliferation, migration, spread and angiogenesis of tumors. KRAS mutations activate MAPK downstream signaling pathways, leading to rapid cell division and proliferation.

KRAS gene has a high mutation rate in various tumors, and it is present in 30%-40% of colorectal cancer patients. The common mutation sites were codons 12 and 13 of exon 2 of KRAS gene. KRAS mutation reduces the efficacy of cetuximab and has a poor prognosis.