Human KRAS Gene Seven Mutation Detection Kit
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KRAS Gene Mutation Detection Kit is a PCR-based in vitro diagnostic test designed to detect 7 somatic mutations in codons 12,13 of KRAS gene in human genomic DNA extracted from formalin-fixed paraffin-embedded (FFPE) tumor samples of clinical tumor patients for targeted drug therapy.
Product Features:
- High Sensitivity: accurately detect 1% of mutant DNA from 10ng of the wild-type gene
- High Specificity: effectively improve the testing specificity by ARMS-PCR detection technology
- High Accuracy: closed tube reaction effectively prevent false negative and false positive results through the standard internal system and UNG enzyme system
- Quick & Easy: easy to operate with reliable results analysis, 90 mins to complete
Product Information
| Cat.No. | Product Name | Technology | Specification | Supply Format |
| YZYMT-001 | Human KRAS Gene Seven Mutation Detection Kit | PCR-Fluorescence Method | 12tests/ kit, 24tests/ kit | CE-IVD/RUO |
Clinical Significance
KRAS is a proto-oncogene and a member of the RAS gene family. The protein encoded by this gene is related to the formation, proliferation, migration, spread and angiogenesis of tumors. KRAS mutations activate MAPK downstream signaling pathways, leading to rapid cell division and proliferation.
KRAS gene has a high mutation rate in various tumors, and it is present in 30%-40% of colorectal cancer patients. The common mutation sites were codons 12 and 13 of exon 2 of KRAS gene. KRAS mutation reduces the efficacy of cetuximab and has a poor prognosis.
Astrid Lie`vre et al. J Clin Oncol. 2008 Jan 20;26(3):374-9
KRAS Gene Corresponding Targeted Drugs
| Molecular Typing | Corresponding Targeted Drugs | Available on Market or not |
| KRAS Mutation | Cetuximab | Yes |
| Panizumab | Yes |
