Human Leukocyte B site 5801 Gene Detection Kit
HLA-B 5801 Gene Detection Kit is a PCR-based in vitro diagnostic test designed to detect polymorphism of HLA-B*5801 gene in whole blood samples. The detection results of this product only represent the detection results for human HLA-B*5801 gene, which provides a reference for the clinical use of allopurinol.
Easy Operation
·Unique fluorescence PCR technology ·Each sample occupies only one reaction well ·90 mins to complete |
Simple Results Analysis
·Simplified analysis without △CT value reading ·Simple training |
Reliable Quality
·With thorough clinical validation, 100% compliance with Sanger sequencing |
Product Information
Cat.No. | Product Name | Technology | Specification | Supply Format |
YZYMT-016 | Human Leukocyte B site 5801 Gene Detection Kit | PCR-Fluorescence Method | 20 tests/ kit | CE-IVD/RUO |
As the first-line drug for the treatment of gout, Allopurinol is a xanthine oxidase inhibitor used primarily for the treatment of gout and the prevention of gouty nephropathy, secondary hyperuricemia,also as the adjunctive treatment of severe epilepsy. However, this drug may cause severe skin adverse reactions(SCARs),such as allergy syndrome (HSS),Stevens-Johnson syndrome(SJS) and toxic epidermal necrolysis(TEN).Numerous studies have shown a strong correlation between theHLA-B*5801 genotype and adverse cutaneous reactions to allopurinol. Meanwhile, those positive family members should be aware of this testing due to the hereditary of this genotype.2020 American College of Rheumatology (ACR) Guideline for the Management of Gout recommends that HLA-B*5801 allele testing should be performed for people with a high risk of severe allergic reactions.
Clinical Significance ( Allopurinol)
Gene Polymorphism | Frequency | Medication Guidance |
HLA-8*5801 | 10%-20% | Individuals with HLA-B*5801 allele gene should
be cautious in using allopurinol |