Human NRAS Gene Mutations Detection Kit

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NRAS Gene Mutations Detection Kit is a PCR-based in vitro diagnostic test designed to detect 9 types of NRAS gene in exons 2, 3 and 4 of NRAS gene in DNA specimen of paraffin-embedded section of patients and provide reference for personalized medicine of clinicians.

Product Features:

High Sensitivity: accurately detect 1% of mutant DNA from 10ng of the wild-type gene
High Specificity: effectively improve the testing specificity by ARMS-PCR detection technology
High Accuracy: closed tube reaction effectively prevent false negative and false positive results through the standard internal system and UNG enzyme system
Quick & Easy: easy to operate with reliable results analysis, 90 mins to complete

Product Information

Cat.No.	Product Name	Technology	Specification	Supply Format
YZYMT-019	Human NRAS Gene Mutations Detection Kit	PCR-Fluorescence Method	12tests/ kit, 24tests/ kit	CE-IVD/RUO

Clinical Significance

NRAS, a member of RAS family with gtpase activity, is a key regulator of cell growth, proliferation and differentiation. Activating mutations of NRAS have been found in a variety of cancers, including melanoma (15-25%) and colorectal cancer (2-6%).

The common mutation sites of NRAS gene located in exon 2, 3 and 4, mainly in codon 12, 13, 59, 61, 117 and 146. Some studies have found that the mutation frequency of NRAS gene exon 2 (codons 12, 13) in colorectal cancer patients with wild-type KRAS gene exon 2 is 3.8%, exon 3 (codons 59, 61) is 4.8%, and exon 4 (codons 117, 146) is 0.5%.

Clinical studies have confirmed that detection of NRAS gene mutation status can predict the treatment response rate of cetuximab in patients with metastatic colorectal cancer.

NRAS Gene Corresponding Targeted Drugs for Colorectal Cancer