Human ROS1 Fusion Gene Detection Kit

Product Features:

• High Sensitivity:  accurately detect 1% of mutant DNA from 10ng of the wild-type gene
• High Specificity:  effectively improve the testing specificity by ARMS-PCR detection technology
• High Accuracy: closed tube reaction effectively prevent false negative and false positive results through the standard internal system and UNG enzyme system
• Quick & Easy: easy to operate with reliable results analysis, 90 mins to complete

Product Information

Clinical Significance

ROS1 encodes a tyrosine kinase belonging to the class II RTK insulin receptor family. Activation of ROS1 kinase induces abnormal cell proliferation and survival. After the fusion and rearrangement of ROS1 gene with SLC34A2, CD74, EZR and other genes, the tyrosine kinase region of the C-terminal region of ROS1 protein is continuously activated, which acts on the downstream signal transduction pathways such as RAS-MAPK/ERK, PI3K/ AKT/mTOR, JAK/STAT3, and leads to cell carcinogenesis. ALK kinase inhibitors can competitively bind to the ROS1 kinase-binding domain and inhibit autophosphorylation at Tyr2774, thereby blocking downstream signaling induced by ROS1 activation.

ROS1 rearrangements represent a new and distinct class of non-small-cell lung cancer, occurring in 1 to 2% of patients, but the frequency increases markedly to 5 to 7% in EGFR/KRAS/ ALK-negative patients, typically in young, nonsmoking patients with lung adenocarcinoma.

Wu Y L , et al. Journal of Clinical Oncology, 2018, 36(14)

ROS1 Fusion Gene Corresponding Targeted Drugs for NSCLC