Colorectal cancer is the third most common cancer worldwide, accounting for about 10% of all cancer cases. Fortunately, the process of normal colorectal mucosa from benign polyp formation to malignant transformation generally takes 5-10 years, which provides a critical window period for early diagnosis and intervention of colorectal cancer. Therefore, early detection, early diagnosis and early treatment are important means of cancer prevention and treatment.
Adhering to the mission of “tailored treatment for people”, YZY MED has launched a new tumor methylation detection product, human SDC2 gene methylation detection kit (PCR-fluorescence probe method), which has officially obtained the registration certificate of Class III Medical Devices of the State Food and Drug Administration (National Registration No.20253400796). With non-invasive, accurate and convenient gene detection technology, Open a new chapter of cancer early screening!
01.Decoding the detection principle of SDC2 methylation
The SDC2 gene encodes connexin 2, which is a key factor in maintaining intercellular signal transduction and inhibiting tumor metastasis. Studies have shown that the hypermethylation of SDC2 gene promoter region can occur in the early stage of colorectal cancer, leading to the inactivation of tumor suppressor function and promoting the proliferation and invasion of cancer cells.
YZY MED uses PCR-fluorescent probe method to design specific primers and probe combinations according to the methylation sequence of human SDC2 gene to achieve accurate capture of SDC2 gene methylation signal in fecal exfoliated cells.
02.Excellent detection performance of the kit
★ Compared with the Sanger sequencing method, the positive coincidence rate of this kit was 100%, the negative coincidence rate was 98.46%, and the total coincidence rate was 98.91%.
★ Compared with the test results of the contrast reagent: the positive coincidence rate of the kit was 100%, the negative coincidence rate was 100%, and the total coincidence rate was 100%.
03.Clinical evidence continues to upgrade
In recent years, SDC2 gene methylation detection has been recommended by many authoritative guidelines and consensus. The approval of YZY MED “Human SDC2 gene methylation detection kit (PCR-fluorescent probe)” is a benchmark work in response to the call of the guidelines!
